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• The P-III (IMPALA-2) study assesses the safety & efficacy of molgramostim (300mcg, self-administered by inhalation, QD) vs PBO for the treatment of aPAP for 48wks.
• The trial previously reached its 1EP, showing significant improvement in hemoglobin-adjusted DLCO% at wk.24, maintained till wk.48. Molgramostim also improved the SGRQ Total Score (2EP) along with SGRQ Activity Score at wk.24 and exercise capacity at wk.48
• New results demonstrated improved disease severity scores and DLCO% responder rates at wks.24 & 48. SGRQ Total Score responder analysis showed higher response rates with molgramostim, that improved at wk.48. GGO score, evaluating surfactant burden, also improved at wk.24. Savara plans to submit the BLA by H1’25

Ref: Savara | Image: Savara

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